APOA4

Across TCGA patient cohorts, APOA4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,486 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOA4-associated genes across cancer lineages are AOC3, MGP, and C7. Each is linked with APOA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOA4-to-partner and partner-to-APOA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOA4 versus AOC3 in BRCA, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA4→partner) and Y-score (partner→APOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AOC3 →	+1.127	+0.576	<.001	<.001	3	9
GBM	MGP →	+1.560	+0.837	<.001	<.001	3	7
OV	C7 →	+2.068	+0.744	.002	.001	3	7
BRCA	RHOJ →	+0.809	+0.571	<.001	<.001	3	7
OV	ABCA8 →	+1.100	+0.745	<.001	.001	3	7
BRCA	LHFPL6 →	+1.067	+0.706	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,486 associations by consensus.

APOA4 vs AOC3 — BRCA

Explore this scatter interactively →