APOA4

Across TCGA patient cohorts, APOA4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOA4-associated genes across cancer lineages are Notch1, FoxM1, and INPP4B. Each is linked with APOA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOA4-to-partner and partner-to-APOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by APOA4-low versus APOA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA4→partner) and Y-score (partner→APOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.211	+2.321	.002	.035	3	3
UCEC	FoxM1 →	+0.268	+3.459	.039	.005	3	2
UCEC	INPP4B →	-0.334	-2.321	.040	.034	3	2
UCEC	Rictor_pT1135 →	-0.136	-2.321	.008	.035	3	2
LUSC	IRS1 →	+0.174	+2.816	.003	.036	1	3
UCEC	eEF2 →	+0.546	+3.169	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Notch1 by APOA4 expression — UCEC

Explore this box plot interactively →