APOA4

Across TCGA cell cohorts, APOA4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOA4-associated genes across cancer lineages are OR1F1, TP53TG3, and NPY2R. Each is linked with APOA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOA4-to-partner and partner-to-APOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1F1 grouped by APOA4-low versus APOA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA4→partner) and Y-score (partner→APOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1F1 →	+0.380	+2.906	<.001	.008	3	1
LARGE_INTESTINE	TP53TG3 →	+0.312	+2.994	.006	.006	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR10D3 →	+0.007	+3.700	<.001	.009	3	1
LARGE_INTESTINE	DPRX →	+0.394	+3.217	.003	.006	3	1
LARGE_INTESTINE	OR8D2 →	+0.028	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR1F1 by APOA4 expression — LARGE_INTESTINE

Explore this box plot interactively →