APOA1

Across TCGA pan-cancer cohorts, APOA1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of APOA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where APOA1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types APOA1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where APOA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.353	<.001	12	view →
COAD	Male	III,IV	−1.119	<.001	10	view →
LUAD	Female	III,IV	−1.703	<.001	9	view →
LSCC	Male	All	−1.415	<.001	8	view →
PDAC	Female	All	+0.773	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

APOA1–HNSC

Open the HNSC breakdown →