APOA1

Across TCGA patient cohorts, APOA1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,647 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOA1-associated genes across cancer lineages are DIPK2B, SLC2A3, and AOC3. Each is linked with APOA1 in more than 7 cancer types. Because this analysis shows association rather than direction, both APOA1-to-partner and partner-to-APOA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOA1 versus DIPK2B in BRCA, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA1→partner) and Y-score (partner→APOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIPK2B →	+0.618	+0.532	<.001	<.001	3	8
LUAD	SLC2A3 →	+1.021	+0.464	<.001	.001	3	8
LSCC	AOC3 →	+0.997	+0.492	<.001	<.001	3	7
BRCA	TPM4 →	+0.722	+0.559	.001	<.001	3	7
GBM	SERPINE1 →	+1.323	+0.494	<.001	<.001	3	6
OV	C7 →	+2.452	+0.814	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,647 associations by consensus.

APOA1 vs DIPK2B — BRCA

Explore this scatter interactively →