APOA1

Across TCGA cell cohorts, APOA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,686 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible APOA1-associated GO terms across cancer lineages are Peptidyl-methionine modification, Regulation of Cdc42 protein signal transduction, and Negative regulation of cholesterol import. Each is linked with APOA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both APOA1-to-partner and partner-to-APOA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-methionine modification grouped by APOA1-low versus APOA1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA1→partner) and Y-score (partner→APOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Peptidyl-methionine modification →	-0.212	-0.509	<.001	<.001	2	10
SOFT_TISSUE	Regulation of Cdc42 protein signal transduction →	-0.203	-0.595	<.001	.009	3	5
LIVER	Negative regulation of cholesterol import →	+2.417	+9.817	<.001	<.001	3	5
BREAST	Regulation of DNA repair →	+0.056	+0.251	<.001	<.001	2	5
BLOOD_Leukemia	Regulation of fibroblast apoptotic process →	-0.065	-0.239	.007	.003	3	4
BONE	Regulation of heart rate by chemical signal →	-0.460	-0.288	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,686 associations by consensus.

Peptidyl-methionine modification by APOA1 expression — SOFT_TISSUE

Explore this box plot interactively →