APLP2

Across TCGA patient cohorts, APLP2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLP2-associated genes across cancer lineages are CLEC10A, SIAE, and LAX1. Each is linked with APLP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both APLP2-to-partner and partner-to-APLP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APLP2 versus CLEC10A in OV, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP2→partner) and Y-score (partner→APLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLEC10A →	-1.449	-0.416	<.001	.002	3	6
LUAD	SIAE →	+0.594	+0.335	.003	.002	3	5
LSCC	LAX1 →	-1.230	-0.407	<.001	<.001	3	5
PDAC	ZNF831 →	-0.804	-0.550	<.001	<.001	3	5
LSCC	IRF4 →	-1.084	-0.324	.001	.003	3	5
HNSC	EI24 →	+0.852	+0.495	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,735 associations by consensus.

APLP2 vs CLEC10A — OV

Explore this scatter interactively →