APLP2

Across TCGA patient cohorts, APLP2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLP2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, STAT3_pY705, and TFRC. Each is linked with APLP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both APLP2-to-partner and partner-to-APLP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by APLP2-low versus APLP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP2→partner) and Y-score (partner→APLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.385	-1.700	.015	.042	3	2
UCEC	STAT3_pY705 →	-0.360	-1.678	<.001	.019	3	2
UCEC	TFRC →	+0.457	+1.662	.014	.011	2	3
UCEC	VHL →	-0.923	-2.222	<.001	.009	3	2
UCEC	ASNS →	+0.510	+1.906	<.001	.015	3	2
UCEC	Cyclin-B1 →	+0.702	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p38-MAPK_pT180_Y182 by APLP2 expression — UCEC

Explore this box plot interactively →