APLP2

Across TCGA cell cohorts, APLP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,313 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APLP2-associated GO terms across cancer lineages are Viral life cycle, Symbiont entry into host, and Symbiont entry into host cell. Each is linked with APLP2 in more than 12 cancer types. Because this analysis shows association rather than direction, both APLP2-to-partner and partner-to-APLP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral life cycle grouped by APLP2-low versus APLP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP2→partner) and Y-score (partner→APLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Viral life cycle →	+0.096	+1.868	<.001	<.001	3	13
BREAST	Symbiont entry into host →	+0.127	+1.179	<.001	<.001	3	12
BREAST	Symbiont entry into host cell →	+0.127	+1.179	<.001	<.001	3	12
BONE	Regulation of focal adhesion assembly →	+0.137	+1.291	.001	.002	3	12
BONE	Regulation of cell-substrate junction assembly →	+0.137	+1.291	.001	.002	3	12
STOMACH	Biological process involved in symbiotic interaction →	+0.115	+1.846	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,313 associations by consensus.

Viral life cycle by APLP2 expression — BONE

Explore this box plot interactively →