APLP2

Across TCGA cell cohorts, APLP2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible APLP2-associated genes across cancer lineages are TRIM49, SLC22A12, and GPR171. Each is linked with APLP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APLP2-to-partner and partner-to-APLP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49 grouped by APLP2-low versus APLP2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP2→partner) and Y-score (partner→APLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TRIM49 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	SLC22A12 →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	GPR171 →	+0.022	+3.688	<.001	.002	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	RPE65 →	+0.441	+4.132	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR52B4 →	+0.011	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TRIM49 by APLP2 expression — URINARY_TRACT

Explore this box plot interactively →