APLP2

Across TCGA cell cohorts, APLP2 mutation is significantly associated with the mutation status of many other genes, with 2,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APLP2-associated genes across cancer lineages are PTPN13, PCDHA10, and SETD2. Each is linked with APLP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both APLP2-to-partner and partner-to-APLP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPN13 grouped by APLP2-low versus APLP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP2→partner) and Y-score (partner→APLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPN13 →	+2.080	+3.906	.003	.003	1	4
LARGE_INTESTINE	PCDHA10 →	+1.781	+3.602	.006	.006	1	4
UPPER_AERODIGESTIVE_TRACT	SETD2 →	+4.392	+4.954	.008	.008	1	4
LUNG_NSCLC_LUAD	ABCB5 →	+2.718	+4.544	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	VPS35L →	+4.392	+4.954	.008	.008	1	3
SKIN	NPC1 →	+4.824	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

PTPN13 by APLP2 expression — LARGE_INTESTINE

Explore this box plot interactively →