APLP1

Across TCGA patient cohorts, APLP1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLP1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and 14-3-3_beta. Each is linked with APLP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APLP1-to-partner and partner-to-APLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by APLP1-low versus APLP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP1→partner) and Y-score (partner→APLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.914	+2.807	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.277	+1.906	<.001	<.001	3	3
COAD	14-3-3_beta →	-0.232	-2.433	.008	.020	3	2
UCEC	eIF4E →	+0.183	+2.920	.002	<.001	3	2
UCEC	Ku80 →	+0.145	+0.956	.035	.042	3	2
UCEC	MEK1 →	+0.402	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by APLP1 expression — UCEC

Explore this box plot interactively →