APLP1

Across TCGA cell cohorts, APLP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,193 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APLP1-associated GO terms across cancer lineages are Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, ATP metabolic process, and Cellular response to aldosterone. Each is linked with APLP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both APLP1-to-partner and partner-to-APLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway grouped by APLP1-low versus APLP1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP1→partner) and Y-score (partner→APLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.201	+3.206	<.001	<.001	3	13
LUNG_SCLC	ATP metabolic process →	+0.069	+1.801	.003	.001	3	12
LUNG_NSCLC_LUSC	Cellular response to aldosterone →	-0.356	-2.492	<.001	<.001	3	12
LIVER	Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.201	+3.395	.001	.003	3	11
OESOPHAGUS	Locomotory exploration behavior →	+0.249	+2.478	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of smoothened signaling pathway →	+0.064	+1.209	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,193 associations by consensus.

Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway by APLP1 expression — SOFT_TISSUE

Explore this box plot interactively →