APLP1

Across TCGA cell cohorts, APLP1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible APLP1-associated genes across cancer lineages are NCBP2L, FAM90A26, and TAAR8. Each is linked with APLP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APLP1-to-partner and partner-to-APLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCBP2L grouped by APLP1-low versus APLP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLP1→partner) and Y-score (partner→APLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NCBP2L →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	FAM90A26 →	+0.016	+4.930	<.001	.008	3	1
BLOOD_Myeloma	TAAR8 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCKAR →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GALR1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MYL1 →	+0.433	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

NCBP2L by APLP1 expression — SOFT_TISSUE

Explore this box plot interactively →