APLNR

Across TCGA patient cohorts, APLNR protein abundance is significantly associated with the RNA expression of many other genes, with 4,733 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APLNR-associated genes across cancer lineages are PIK3IP1, CRYBB1, and SOX10. Each is linked with APLNR in more than 1 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APLNR versus PIK3IP1 in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3IP1 →	+0.613	+0.798	<.001	<.001	3	1
GBM	CRYBB1 →	+0.540	+0.780	<.001	<.001	3	1
GBM	SOX10 →	+1.087	+0.904	.007	<.001	3	1
GBM	CENPM →	-0.641	-0.782	.001	<.001	3	1
GBM	CYB5R3 →	+0.367	+1.020	.001	<.001	3	1
GBM	CHADL →	+0.725	+0.760	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,733 associations by consensus.

APLNR vs PIK3IP1 — GBM

Explore this scatter interactively →