APLNR

Across TCGA patient cohorts, APLNR mutation is significantly associated with the RNA expression of many other genes, with 2,878 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLNR-associated genes across cancer lineages are FANCG, MRPL37, and TCF3. Each is linked with APLNR in more than 3 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCG grouped by APLNR-low versus APLNR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCG →	+0.441	+2.021	.003	.001	3	4
UCEC	MRPL37 →	+0.453	+2.711	.001	<.001	3	4
UCEC	TCF3 →	+0.454	+1.684	.003	.007	3	4
SKCM	HINFP →	+0.292	+3.179	.001	<.001	3	4
SKCM	UQCRH →	+0.422	+2.623	<.001	<.001	3	4
SKCM	NR2C2AP →	+0.368	+2.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,878 associations by consensus.

FANCG by APLNR expression — UCEC

Explore this box plot interactively →