APLNR

Across TCGA patient cohorts, APLNR mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLNR-associated genes across cancer lineages are Cyclin-B1, Rictor_pT1135, and P-Cadherin. Each is linked with APLNR in more than 2 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by APLNR-low versus APLNR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.625	+3.321	.004	.009	3	3
SKCM	Rictor_pT1135 →	-0.128	-1.781	.018	.024	3	3
STAD	P-Cadherin →	-0.175	-3.000	.018	.036	3	2
STAD	Chk2 →	+0.353	+3.000	.029	.036	3	2
UCEC	Ku80 →	+0.260	+2.515	.005	.001	3	2
UCEC	Shc_pY317 →	-0.186	-2.906	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-B1 by APLNR expression — UCEC

Explore this box plot interactively →