APLNR

Across TCGA cell cohorts, APLNR RNA expression is significantly associated with the go_rna of many other GO terms, with 1,177 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APLNR-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum unfolded protein response, Cellular response to nutrient levels, and Regulation of proteasomal protein catabolic process. Each is linked with APLNR in more than 5 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum unfolded protein response grouped by APLNR-low versus APLNR-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.086	+0.744	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Cellular response to nutrient levels →	+0.062	+0.032	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of proteasomal protein catabolic process →	+0.061	+0.065	<.001	.008	3	5
BLOOD_Leukemia	Negative regulation of response to endoplasmic reticulum stress →	+0.044	+0.539	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.079	+0.047	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.099	+0.031	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

Negative regulation of endoplasmic reticulum unfolded protein response by APLNR expression — BLOOD_Leukemia

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