APLNR

Across TCGA cell cohorts, APLNR mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible APLNR-associated genes across cancer lineages are PRSS58, IL21, and PPP1R3A. Each is linked with APLNR in more than 1 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by APLNR-low versus APLNR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	IL21 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PPP1R3A →	+0.036	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP6-1 →	+0.073	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR13C2 →	+0.026	+4.887	<.001	.009	3	1
LARGE_INTESTINE	HSFY1 →	+0.019	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRSS58 by APLNR expression — SKIN

Explore this box plot interactively →