APLNR

Across TCGA cell cohorts, APLNR mutation is significantly associated with the mutation status of many other genes, with 1,302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APLNR-associated genes across cancer lineages are ARHGAP42, ENDOV, and ANGEL2. Each is linked with APLNR in more than 1 cancer types. Because this analysis shows association rather than direction, both APLNR-to-partner and partner-to-APLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP42 grouped by APLNR-low versus APLNR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLNR→partner) and Y-score (partner→APLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGAP42 →	+4.824	+5.392	.004	.004	1	2
SKIN	ENDOV →	+4.239	+5.053	.007	.007	1	2
SKIN	ANGEL2 →	+4.824	+5.392	.004	.004	1	2
SKIN	OR6B3 →	+4.824	+5.392	.004	.004	1	2
SKIN	MGAT4C →	+4.239	+5.053	.007	.007	1	2
SKIN	CNOT10 →	+4.239	+5.053	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,302 associations by consensus.

ARHGAP42 by APLNR expression — SKIN

Explore this box plot interactively →