APLN

Across TCGA patient cohorts, APLN mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLN-associated genes across cancer lineages are A-Raf_pS299, p62 Lck ligand, and PDK1_pS241. Each is linked with APLN in more than 1 cancer types. Because this analysis shows association rather than direction, both APLN-to-partner and partner-to-APLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by APLN-low versus APLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLN→partner) and Y-score (partner→APLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.205	-3.584	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.390	+2.179	.007	.034	3	1
UCEC	PDK1_pS241 →	+0.186	+2.833	.015	.034	3	1
UCEC	Annexin-1 →	+0.645	+3.189	.006	.010	3	1
UCEC	Tuberin →	+0.392	+3.169	.001	.018	3	1
UCEC	ATM →	-0.489	-2.000	.016	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by APLN expression — UCEC

Explore this box plot interactively →