APLN

Across TCGA cell cohorts, APLN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,363 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible APLN-associated GO terms across cancer lineages are Apelin receptor signaling pathway, Peptidyl-lysine oxidation, and Positive regulation of G protein-coupled receptor internalization. Each is linked with APLN in more than 16 cancer types. Because this analysis shows association rather than direction, both APLN-to-partner and partner-to-APLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Apelin receptor signaling pathway grouped by APLN-low versus APLN-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APLN→partner) and Y-score (partner→APLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Apelin receptor signaling pathway →	+1.591	+3.540	<.001	<.001	3	17
URINARY_TRACT	Peptidyl-lysine oxidation →	+1.518	+1.034	<.001	.005	3	14
LUNG_SCLC	Positive regulation of G protein-coupled receptor internalization →	-0.303	-2.203	<.001	<.001	1	15
URINARY_TRACT	Negative regulation of dendritic cell apoptotic process →	+1.565	+1.438	<.001	<.001	3	11
URINARY_TRACT	Regulation of G protein-coupled receptor internalization →	-0.180	-1.762	<.001	<.001	3	11
LUNG_NSCLC_LUSC	PML body organization →	+0.207	+0.966	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

Apelin receptor signaling pathway by APLN expression — KIDNEY

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