APLF

Across TCGA pan-cancer cohorts, APLF mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of APLF’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where APLF mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types APLF is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

LUAD, CCRCC, and LSCC are the cancer types where APLF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APLF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.772	<.001	8	view →
CCRCC	Male	All	+0.398	<.001	6	view →
LSCC	Male	All	+0.297	<.001	5	view →
OV	All	All	−0.657	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

APLF–LUAD

Open the LUAD breakdown →