Across TCGA pan-cancer cohorts, API5P2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of API5P2’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where API5P2 RNA is repressed in tumor relative to normal tissue. In most cancer types API5P2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, BRCA, and COAD are the cancer types where API5P2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in API5P2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.