API5P1

Across TCGA patient cohorts, API5P1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,806 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible API5P1-associated GO terms across cancer lineages are Ribosome-associated ubiquitin-dependent protein catabolic process, Positive regulation of mRNA 3'-end processing, and Glycosylation. Each is linked with API5P1 in more than 29 cancer types. Because this analysis shows association rather than direction, both API5P1-to-partner and partner-to-API5P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosome-associated ubiquitin-dependent protein catabolic process grouped by API5P1-low versus API5P1-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (API5P1→partner) and Y-score (partner→API5P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.103	+0.228	<.001	<.001	3	30
DLBC	Positive regulation of mRNA 3'-end processing →	+0.082	+0.236	<.001	<.001	3	29
ESCA	Glycosylation →	+0.043	+0.311	.003	<.001	3	28
THYM	Positive regulation of translation in response to stress →	+0.067	+0.102	<.001	<.001	3	28
ESCA	Regulation of translation in response to stress →	+0.075	+0.285	.001	<.001	3	28
ESCA	Regulation of translational initiation in response to stress →	+0.082	+0.328	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,806 associations by consensus.

Ribosome-associated ubiquitin-dependent protein catabolic process by API5P1 expression — DLBC

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