API5

Across TCGA patient cohorts, API5 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible API5-associated genes across cancer lineages are JNK2, Notch1, and Tuberin. Each is linked with API5 in more than 1 cancer types. Because this analysis shows association rather than direction, both API5-to-partner and partner-to-API5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by API5-low versus API5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (API5→partner) and Y-score (partner→API5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.173	+1.512	.004	.017	3	2
UCEC	Notch1 →	+0.108	+1.691	.010	.011	3	2
UCEC	Tuberin →	+0.328	+3.087	<.001	<.001	3	2
UCEC	ATM →	-0.336	-1.687	.014	.040	3	2
UCEC	Caspase-8 →	-0.270	-1.999	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.534	+1.847	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

JNK2 by API5 expression — UCEC

Explore this box plot interactively →