API5

Across TCGA cell cohorts, API5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible API5-associated genes across cancer lineages are FAM187B, GOLGA6L1, and CABP5. Each is linked with API5 in more than 1 cancer types. Because this analysis shows association rather than direction, both API5-to-partner and partner-to-API5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM187B grouped by API5-low versus API5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (API5→partner) and Y-score (partner→API5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM187B →	+0.072	+4.684	<.001	.002	3	1
SKIN	GOLGA6L1 →	+0.013	+4.684	<.001	.002	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP19-5 →	+0.040	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	FCN2 →	+0.543	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRLH →	+0.208	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM187B by API5 expression — SKIN

Explore this box plot interactively →