APH1A

Across TCGA pan-cancer cohorts, APH1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated APH1A data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher APH1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APH1A expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where APH1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.320	0.865	.002	7	view →
CCRCC	DFS	Quartile	III,IV	0.236	1.000	.036	4	view →
GBM	OS	Median	All	0.855	0.671	.021	2	view →
LUAD	DFS	Tertile	III,IV	0.718	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

APH1A–HNSC (DFS)

Open the HNSC breakdown →