APH1A

Across TCGA patient cohorts, APH1A mutation is significantly associated with the RNA expression of many other genes, with 1,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APH1A-associated genes across cancer lineages are RNA5SP131, RNA5SP198, and RNA5SP405. Each is linked with APH1A in more than 1 cancer types. Because this analysis shows association rather than direction, both APH1A-to-partner and partner-to-APH1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP131 grouped by APH1A-low versus APH1A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1A→partner) and Y-score (partner→APH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP131 →	+0.270	+4.757	<.001	.004	3	2
CESC	RNA5SP198 →	+0.218	+4.559	<.001	.006	3	2
UCEC	RNA5SP405 →	+0.306	+3.260	<.001	.004	3	2
HNSC	RNU105C →	+0.201	+4.578	<.001	.008	3	2
HNSC	RNA5SP235 →	+0.411	+6.623	<.001	<.001	3	2
HNSC	RNU6-318P →	+0.256	+4.655	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,213 associations by consensus.

RNA5SP131 by APH1A expression — CESC

Explore this box plot interactively →