APH1A

Across TCGA patient cohorts, APH1A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APH1A-associated genes across cancer lineages are ATM, EGFR_pY1068, and FoxM1. Each is linked with APH1A in more than 2 cancer types. Because this analysis shows association rather than direction, both APH1A-to-partner and partner-to-APH1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by APH1A-low versus APH1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1A→partner) and Y-score (partner→APH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.574	-2.584	.006	.011	3	3
UCEC	EGFR_pY1068 →	-0.265	-2.584	.023	.011	3	1
UCEC	FoxM1 →	+0.322	+2.584	.007	.011	3	1
UCEC	MEK1 →	+0.415	+3.700	.014	.001	3	1
UCEC	Notch1 →	+0.231	+2.179	<.001	.034	3	1
UCEC	Rab25 →	-0.637	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by APH1A expression — UCEC

Explore this box plot interactively →