APH1A

Across TCGA cell cohorts, APH1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,212 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APH1A-associated GO terms across cancer lineages are Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11), Regulation of CD8-positive, alpha-beta T cell differentiation, and Protein polyubiquitination. Each is linked with APH1A in more than 8 cancer types. Because this analysis shows association rather than direction, both APH1A-to-partner and partner-to-APH1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) grouped by APH1A-low versus APH1A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1A→partner) and Y-score (partner→APH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.099	+0.533	<.001	.002	3	9
LIVER	Regulation of CD8-positive, alpha-beta T cell differentiation →	+0.183	+0.628	.006	.001	3	9
BLOOD_Lymphoma	Protein polyubiquitination →	+0.027	+0.683	.002	.002	3	9
LUNG_NSCLC_LUSC	Threonyl-tRNA aminoacylation →	+0.238	+0.710	.001	.001	3	9
LUNG_NSCLC_LUAD	Peroxisome fission →	+0.118	+0.744	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.040	+0.512	.003	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) by APH1A expression — OVARY

Explore this box plot interactively →