APEX2

Across TCGA patient cohorts, APEX2 mutation is significantly associated with the RNA expression of many other genes, with 888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APEX2-associated genes across cancer lineages are ANAPC1P6, CYP2C61P, and IGKV3D-34. Each is linked with APEX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APEX2-to-partner and partner-to-APEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANAPC1P6 grouped by APEX2-low versus APEX2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX2→partner) and Y-score (partner→APEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ANAPC1P6 →	+0.070	+4.601	<.001	.004	3	2
BLCA	CYP2C61P →	+0.156	+5.147	<.001	.003	3	2
LUAD	IGKV3D-34 →	+0.138	+5.712	<.001	.003	3	2
BLCA	RNU6-841P →	+0.318	+5.018	<.001	.004	3	2
UCEC	RNU6-508P →	+0.167	+2.499	<.001	.005	3	2
BLCA	MIR875 →	+0.370	+4.685	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

ANAPC1P6 by APEX2 expression — CESC

Explore this box plot interactively →