APEX2

Across TCGA patient cohorts, APEX2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APEX2-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and eIF4G. Each is linked with APEX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APEX2-to-partner and partner-to-APEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by APEX2-low versus APEX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX2→partner) and Y-score (partner→APEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.123	-1.886	.013	.015	3	2
UCEC	eIF4E →	+0.159	+2.201	.024	<.001	3	1
UCEC	eIF4G →	+0.248	+1.874	.017	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-2.415	.001	.003	3	1
UCEC	MEK1 →	+0.253	+1.847	.038	.007	3	1
UCEC	Notch1 →	+0.122	+1.594	.009	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

mTOR_pS2448 by APEX2 expression — UCEC

Explore this box plot interactively →