APEX2

Across TCGA cell cohorts, APEX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,206 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APEX2-associated GO terms across cancer lineages are Mitotic spindle elongation, Spindle elongation, and Mitotic spindle midzone assembly. Each is linked with APEX2 in more than 14 cancer types. Because this analysis shows association rather than direction, both APEX2-to-partner and partner-to-APEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle elongation grouped by APEX2-low versus APEX2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX2→partner) and Y-score (partner→APEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Mitotic spindle elongation →	+0.242	+0.786	<.001	<.001	3	15
KIDNEY	Spindle elongation →	+0.295	+0.761	<.001	.001	3	15
OVARY	Mitotic spindle midzone assembly →	+0.242	+0.786	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.151	+0.918	.001	<.001	3	15
BONE	Negative regulation of heterochromatin organization →	+0.145	+0.824	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.083	+0.874	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

Mitotic spindle elongation by APEX2 expression — OVARY

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