APEX2

Across TCGA cell cohorts, APEX2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible APEX2-associated genes across cancer lineages are CRX and CCL23. Each is linked with APEX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APEX2-to-partner and partner-to-APEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRX grouped by APEX2-low versus APEX2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX2→partner) and Y-score (partner→APEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRX →	+0.005	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	CCL23 →	+0.065	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CRX by APEX2 expression — SKIN

Explore this box plot interactively →