APEX1

Across TCGA pan-cancer cohorts, APEX1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated APEX1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher APEX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APEX1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

HNSC, LSCC, and COAD are the cancer types where APEX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.626	0.915	.001	74	view →
LSCC	DFS	Median	II,III,IV	0.867	0.521	<.001	41	view →
COAD	DFS	Median	All	1.000	0.920	.014	24	view →
UCEC	OS	Tertile	II,III,IV	0.464	1.000	.008	18	view →
GBM	DFS	Tertile	All	0.495	0.313	.023	6	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	5	view →
PDAC	OS	Quartile	III,IV	0.543	0.977	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

APEX1–HNSC (DFS)

Open the HNSC breakdown →