APEX1

Across TCGA cell cohorts, APEX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,229 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APEX1-associated GO terms across cancer lineages are Endothelial to hematopoietic transition, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Granzyme-mediated apoptotic signaling pathway. Each is linked with APEX1 in more than 14 cancer types. Because this analysis shows association rather than direction, both APEX1-to-partner and partner-to-APEX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial to hematopoietic transition grouped by APEX1-low versus APEX1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX1→partner) and Y-score (partner→APEX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Endothelial to hematopoietic transition →	+0.107	+0.560	<.001	.001	3	15
URINARY_TRACT	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.100	+0.870	<.001	<.001	2	15
UPPER_AERODIGESTIVE_TRACT	Granzyme-mediated apoptotic signaling pathway →	+0.115	+1.225	<.001	<.001	3	14
BONE	Cellular response to unfolded protein →	-0.077	-0.496	<.001	.001	3	13
LUNG_NSCLC_LUSC	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.122	+0.778	.001	.001	3	13
URINARY_TRACT	Maturation of 5.8S rRNA →	+0.096	+1.123	.007	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,229 associations by consensus.

Endothelial to hematopoietic transition by APEX1 expression — KIDNEY

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