APEH

Across TCGA patient cohorts, APEH mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APEH-associated genes across cancer lineages are eIF4E, FASN, and ACC1. Each is linked with APEH in more than 2 cancer types. Because this analysis shows association rather than direction, both APEH-to-partner and partner-to-APEH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by APEH-low versus APEH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APEH→partner) and Y-score (partner→APEH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+3.459	.032	.005	3	3
UCEC	FASN →	+0.478	+2.999	.005	.035	3	2
UCEC	ACC1 →	+0.383	+3.183	.015	.009	3	2
UCEC	Ku80 →	+0.254	+2.820	.014	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.562	+2.189	.030	.034	3	2
UCEC	FoxM1 →	+0.238	+2.115	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by APEH expression — UCEC

Explore this box plot interactively →