APEH

Across TCGA cell cohorts, APEH mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APEH-associated genes across cancer lineages are OR10R2, LGI1, and C20orf85. Each is linked with APEH in more than 1 cancer types. Because this analysis shows association rather than direction, both APEH-to-partner and partner-to-APEH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by APEH-low versus APEH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APEH→partner) and Y-score (partner→APEH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.529	+4.551	.001	.004	3	2
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.023	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.075	+4.276	<.001	.007	3	1
BLOOD_Leukemia	TPRX1 →	+0.021	+5.060	<.001	.001	3	1
BLOOD_Leukemia	PRR30 →	+0.019	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR10R2 by APEH expression — BLOOD_Leukemia

Explore this box plot interactively →