Across TCGA patient cohorts, APCDD1L mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APCDD1L-associated genes across cancer lineages are Cyclin-E2, Caspase-7-cleavedD198, and Notch1. Each is linked with APCDD1L in more than 1 cancer types. Because this analysis shows association rather than direction, both APCDD1L-to-partner and partner-to-APCDD1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCDD1L→partner) and Y-score (partner→APCDD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.210	+2.817	.007	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.099	+3.008	.007	.019	3	2
UCEC	Notch1 →	+0.131	+2.179	.045	.034	3	1
UCEC	p38-MAPK →	-0.174	-2.979	.023	.036	3	1
UCEC	P-Cadherin →	-0.141	-2.999	.036	.035	3	1
UCEC	PTEN →	-0.431	-2.999	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

APCDD1L survival (RNA) · tumor vs normal (RNA) · all APCDD1L data types