Across TCGA cell cohorts, APCDD1L mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APCDD1L-associated genes across cancer lineages are MRGPRX4, CTAGE6, and SEPTIN3. Each is linked with APCDD1L in more than 1 cancer types. Because this analysis shows association rather than direction, both APCDD1L-to-partner and partner-to-APCDD1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCDD1L→partner) and Y-score (partner→APCDD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MRGPRX4 →	+0.023	+4.169	<.001	.001	3	1
LUNG_SCLC	CTAGE6 →	+0.077	+4.070	<.001	.003	3	1
LARGE_INTESTINE	SEPTIN3 →	+1.079	+3.252	.003	.002	3	1
LARGE_INTESTINE	ZMYND8 →	-0.801	-3.321	.001	.003	3	1
LARGE_INTESTINE	ADNP2 →	+0.766	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	RBFA →	+0.682	+2.502	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

Exploration

APCDD1L survival (RNA) · tumor vs normal (RNA) · all APCDD1L data types