APCDD1

Across TCGA patient cohorts, APCDD1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APCDD1-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with APCDD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APCDD1-to-partner and partner-to-APCDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by APCDD1-low versus APCDD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCDD1→partner) and Y-score (partner→APCDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+2.000	.025	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.523	+2.479	.016	.010	3	2
UCEC	4E-BP1 →	+0.352	+3.936	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.076	-3.143	.040	.018	3	1
UCEC	eIF4E →	+0.213	+3.807	.005	<.001	2	2
UCEC	A-Raf_pS299 →	-0.122	-2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by APCDD1 expression — UCEC

Explore this box plot interactively →