APC2

Across TCGA patient cohorts, APC2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APC2-associated genes across cancer lineages are TFRC, INPP4B, and LKB1. Each is linked with APC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both APC2-to-partner and partner-to-APC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by APC2-low versus APC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APC2→partner) and Y-score (partner→APC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.613	+2.321	.027	.035	3	3
COAD	INPP4B →	-0.442	-3.000	.008	.034	3	2
COAD	LKB1 →	+0.116	+2.330	.009	.020	3	2
COAD	14-3-3_epsilon →	+0.191	+2.364	<.001	.018	3	2
COAD	ATM →	-0.583	-2.313	<.001	.035	3	2
COAD	Bid →	+0.118	+2.841	.021	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TFRC by APC2 expression — SKCM

Explore this box plot interactively →