APC2

Across TCGA cell cohorts, APC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,850 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible APC2-associated GO terms across cancer lineages are SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Calcium-independent cell-matrix adhesion, and Regulation of protein localization to centrosome. Each is linked with APC2 in more than 12 cancer types. Because this analysis shows association rather than direction, both APC2-to-partner and partner-to-APC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process grouped by APC2-low versus APC2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APC2→partner) and Y-score (partner→APC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.056	+1.228	<.001	<.001	3	13
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.174	+0.264	<.001	<.001	2	13
LUNG_SCLC	Regulation of protein localization to centrosome →	+0.130	+2.007	<.001	<.001	3	11
STOMACH	Positive regulation of double-strand break repair →	+0.060	+0.721	.003	.004	3	11
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.140	+1.503	<.001	<.001	3	11
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.090	+2.164	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process by APC2 expression — SOFT_TISSUE

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