APC2

Across TCGA cell cohorts, APC2 mutation is significantly associated with the RNA expression of many other genes, with 1,563 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APC2-associated genes across cancer lineages are TRAPPC13, SCAI, and ERCC8. Each is linked with APC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both APC2-to-partner and partner-to-APC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC13 grouped by APC2-low versus APC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APC2→partner) and Y-score (partner→APC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRAPPC13 →	+0.413	+2.700	.002	.001	3	3
LARGE_INTESTINE	SCAI →	+0.515	+2.129	<.001	.001	3	3
LARGE_INTESTINE	ERCC8 →	+0.455	+3.321	<.001	.003	2	4
URINARY_TRACT	GABRD →	+0.365	+3.485	.006	.001	3	2
SKIN	SYNDIG1 →	+0.732	+4.055	<.001	<.001	3	2
SKIN	FBN3 →	+0.403	+2.706	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,563 associations by consensus.

TRAPPC13 by APC2 expression — LARGE_INTESTINE

Explore this box plot interactively →