APC

Across TCGA pan-cancer cohorts, APC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated APC data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher APC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APC expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where APC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.809	1.000	.012	19	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.314	.017	9	view →
GBM	OS	Median	All	0.525	0.265	.001	8	view →
HNSC	OS	Quartile	III,IV	0.791	0.526	.031	2	view →
PDAC	OS	Median	II,III,IV	0.403	0.577	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

APC–CCRCC (DFS)

Open the CCRCC breakdown →