APC

Across TCGA patient cohorts, APC mutation is significantly associated with the RNA expression of many other genes, with 8,993 significant associations in total. COAD shows the largest number of these associations.

The most reproducible APC-associated genes across cancer lineages are HSPA9, POLR1D, and XRCC2. Each is linked with APC in more than 5 cancer types. Because this analysis shows association rather than direction, both APC-to-partner and partner-to-APC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPA9 grouped by APC-low versus APC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APC→partner) and Y-score (partner→APC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HSPA9 →	+0.382	+3.660	.005	.001	3	6
COAD	POLR1D →	+0.303	+0.769	<.001	<.001	3	5
STAD	XRCC2 →	+0.494	+2.165	.005	.008	3	5
LUAD	LIG1 →	+0.599	+3.459	.001	.005	3	5
STAD	RBM28 →	+0.335	+2.957	.003	<.001	3	5
STAD	EXOSC8 →	+0.444	+2.371	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,993 associations by consensus.

HSPA9 by APC expression — SKCM

Explore this box plot interactively →