APC

Across TCGA cell cohorts, APC mutation is significantly associated with the RNA expression of many other genes, with 597 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APC-associated genes across cancer lineages are VPS26A, KIF3A, and DENND10. Each is linked with APC in more than 2 cancer types. Because this analysis shows association rather than direction, both APC-to-partner and partner-to-APC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS26A grouped by APC-low versus APC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APC→partner) and Y-score (partner→APC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VPS26A →	+0.469	+0.758	.004	.001	3	3
BLOOD_Leukemia	KIF3A →	+1.371	+3.351	<.001	.003	3	3
STOMACH	DENND10 →	+0.708	+2.670	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	OR1L4 →	+0.054	+2.777	.002	.008	3	3
LUNG_SCLC	KRTAP10-12 →	+0.158	+3.705	<.001	<.001	3	2
SOFT_TISSUE	MMP26 →	+0.056	+3.584	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 597 associations by consensus.

VPS26A by APC expression — LARGE_INTESTINE

Explore this box plot interactively →