APBB3

Across TCGA patient cohorts, APBB3 mutation is significantly associated with the RNA expression of many other genes, with 3,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB3-associated genes across cancer lineages are PSMB7, IGHD3-22, and MIR5100. Each is linked with APBB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBB3-to-partner and partner-to-APBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB7 grouped by APBB3-low versus APBB3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB3→partner) and Y-score (partner→APBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMB7 →	+0.374	+3.219	.005	.009	3	3
BLCA	IGHD3-22 →	+1.365	+4.241	.001	.003	3	3
BRCA	MIR5100 →	+0.302	+5.382	<.001	.003	3	2
LUSC	OR11H2 →	+0.062	+5.792	.001	.003	3	2
UCEC	CENPM →	+0.502	+2.000	.003	.001	3	2
UCEC	TXN2 →	+0.346	+2.797	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,766 associations by consensus.

PSMB7 by APBB3 expression — COAD

Explore this box plot interactively →