APBB3

Across TCGA patient cohorts, APBB3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB3-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and mTOR_pS2448. Each is linked with APBB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBB3-to-partner and partner-to-APBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by APBB3-low versus APBB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB3→partner) and Y-score (partner→APBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.349	+2.817	.003	.001	3	3
UCEC	EGFR_pY1068 →	-0.255	-3.459	.005	.005	3	2
UCEC	mTOR_pS2448 →	-0.160	-3.571	.003	.002	3	2
UCEC	AMPK_alpha →	-0.153	-2.222	.029	.010	3	2
UCEC	Annexin-1 →	+0.520	+3.479	.007	.002	3	2
UCEC	Stathmin →	+0.143	+2.611	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

p62 Lck ligand by APBB3 expression — UCEC

Explore this box plot interactively →